Chaix Lab

Research in the Chaix Lab seek to uncover the mechanisms by which diet-induced obesity contributes to type 2 diabetes (T2D) and breast cancer (BC), as foundations to developing novel pharmacological and dietary strategies to improve the lives of individuals affected by obesity and obesity-accelerated cancers.

We use a variety of dietary and genetic mouse models of obesity and metabolic disease, along with diverse nutritional and pharmacological interventions, including calorie restriction (CR), time-restricted feeding (TRF), ketogenic diet (KD) and incretin mimetics. By applying cutting-edge cellular, molecular and bioinformatics approaches to both preclinical models and patient samples, we aim to uncover translationally relevant pathways through which obesity and weight loss affect metabolic tissue function and breast cancer development.