Publications
2024
Chaix A, Lin T, Ramms B, Cutler RG, Le T, Lopez C, Miu P, Pinto AFM, Saghatelian A, Playford MP, Mehta NN, Mattson MP, Gordts P, Witztum JL, Panda S. Time-Restricted Feeding Reduces Atherosclerosis in LDLR KO Mice but Not in ApoE Knockout Mice. Arterioscler Thromb Vasc Biol. 2024. Epub 2024/08/01. doi: 10.1161/ATVBAHA.124.320998. PubMed PMID: 39087348.
Gallop MR, Vieira RF, Matsuzaki ET, Mower PD, Liou W, Smart FE, Roberts S, Evason KJ, Holland WL, Chaix A. Long-term ketogenic diet causes hyperlipidemia, liver dysfunction, and glucose intolerance from impaired insulin trafficking and secretion in mice. bioRxiv. 2024:2024.06.14.599117. doi: 10.1101/2024.06.14.599117.
2023
Damasceno de Lima R, Fudoli Lins Vieira R, Rosetto Munoz V, Chaix A, Azevedo Macedo AP, Calheiros Antunes G, Felonato M, Rosseto Braga R, Castelo Branco Ramos Nakandakari S, Calais Gaspar R, Ramos da Silva AS, Esper Cintra D, Pereira de Moura L, Mekary RA, Rochete Ropelle E, Pauli JR. Time-restricted feeding combined with resistance exercise prevents obesity and improves lipid metabolism in the liver of mice fed a high-fat diet. Am J Physiol Endocrinol Metab. 2023;325(5):E513-E28. Epub 2023/09/27. doi: 10.1152/ajpendo.00129.2023. PubMed PMID: 37755454; PMCID: PMC10864020.
Deota S, Lin T, Chaix A, Williams A, Le H, Calligaro H, Ramasamy R, Huang L, Panda S. Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals. Cell Metab. 2023;35(1):150-65 e4. Epub 2023/01/05. doi: 10.1016/j.cmet.2022.12.006. PubMed PMID: 36599299; PMCID: PMC10026518.
Ferrara PJ, Lang MJ, Johnson JM, Watanabe S, McLaughlin KL, Maschek JA, Verkerke ARP, Siripoksup P, Chaix A, Cox JE, Fisher-Wellman KH, Funai K. Weight loss increases skeletal muscle mitochondrial energy efficiency in obese mice. Life Metab. 2023;2(2). Epub 2023/05/19. doi: 10.1093/lifemeta/load014. PubMed PMID: 37206438; PMCID: PMC10195096.
Handzlik MK, Gengatharan JM, Frizzi KE, McGregor GH, Martino C, Rahman G, Gonzalez A, Moreno AM, Green CR, Guernsey LS, Lin T, Tseng P, Ideguchi Y, Fallon RJ, Chaix A, Panda S, Mali P, Wallace M, Knight R, Gantner ML, Calcutt NA, Metallo CM. Insulin-regulated serine and lipid metabolism drive peripheral neuropathy. Nature. 2023;614(7946):118-24. Epub 2023/01/26. doi: 10.1038/s41586-022-05637-6. PubMed PMID: 36697822; PMCID: PMC9891999 no competing interests.
Mihaylova MM, Chaix A, Delibegovic M, Ramsey JJ, Bass J, Melkani G, Singh R, Chen Z, Ja WW, Shirasu-Hiza M, Latimer MN, Mattison JA, Thalacker-Mercer AE, Dixit VD, Panda S, Lamming DW. When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging. Cell Metab. 2023;35(7):1114-31. Epub 2023/07/02. doi: 10.1016/j.cmet.2023.06.008. PubMed PMID: 37392742; PMCID: PMC10528391.
Peterson L, Lee H, Huybrechts I, Biessy C, Neuhouser ML, Haaland B, Krick B, Gunter M, Schulze MB, Jannasch F, Coletta AM, Hardikar S, Chaix A, Bauer CX, Xiao Q, Playdon MC. Reliability estimates for assessing meal timing derived from longitudinal repeated 24-hour dietary recalls. Am J Clin Nutr. 2023;117(5):964-75. Epub 2023/03/16. doi: 10.1016/j.ajcnut.2023.02.026. PubMed PMID: 36921904; PMCID: PMC10206325
Petrocelli JJ, de Hart N, Lang MJ, Yee EM, Ferrara PJ, Fix DK, Chaix A, Funai K, Drummond MJ. Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail. Aging (Albany NY). 2023;15(6):1808-32. Epub 2023/03/23. doi: 10.18632/aging.204600. PubMed PMID: 36947713; PMCID: PMC10085594.
Rey-Serra C, Tituana J, Lin T, Herrero JI, Miguel V, Barbas C, Meseguer A, Ramos R, Chaix A, Panda S, Lamas S. Reciprocal regulation between the molecular clock and kidney injury. Life Sci Alliance. 2023;6(10). Epub 2023/07/25. doi: 10.26508/lsa.202201886. PubMed PMID: 37487638; PMCID: PMC10366531.
2022
Chaix A. Time-Restricted Feeding and Caloric Restriction: Two Feeding Regimens at the Crossroad of Metabolic and Circadian Regulation. Methods Mol Biol. 2022;2482:329-40. Epub 2022/05/25. PubMed PMID: 35610437; PMCID: PMC9254535.
Dantas Machado AC, Brown SD, Lingaraju A, Sivaganesh V, Martino C, Chaix A, Zhao P, Pinto AFM, Chang MW, Richter RA, Saghatelian A, Saltiel AR, Knight R, Panda S, Zarrinpar A. Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome. Cell Rep. 2022;40(1):111008. Epub 2022/07/07. doi: 10.1016/j.celrep.2022.111008. PubMed PMID: 35793637; PMCID: PMC9296000.
Gallop MR, Tobin SY, Chaix A. Finding balance: understanding the energetics of time-restricted feeding in mice. Obesity (Silver Spring, Md). 2022. doi: 10.1002/oby.23607.
Petersen MC, Gallop MR, Flores Ramos S, Zarrinpar A, Broussard JL, Chondronikola M, Chaix A, Klein S. Complex physiology and clinical implications of time-restricted eating. Physiol Rev. 2022;102(4):1991-2034. Epub 2022/07/15. doi: 10.1152/physrev.00006.2022. PubMed PMID: 35834774; PMCID: PMC9423781.
2021
Chaix A, Deota S, Bhardwaj R, Lin T, Panda S. Sex- and age-dependent outcomes of 9-hour time-restricted feeding of a Western high-fat high-sucrose diet in C57BL/6J mice. Cell Rep. 2021;36(7):109543. Epub 2021/08/19. doi: 10.1016/j.celrep.2021.109543. PubMed PMID: 34407415; PMCID: PMC8500107.
Chaix A, Rynders CA. Time restricted feeding plus exercise: could two be better than one for metabolic health? J Physiol. 2022;600(4):699-700. Epub 2021/02/04. doi: 10.1113/JP281358. PubMed PMID: 33533524; PMCID: PMC8329115.
2019
Chaix A, Lin T, Le HD, Chang MW, Panda S. Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock. Cell Metab. 2019;29(2):303-19 e4. Epub 2018/09/04. PubMed PMID: 30174302; PMCID: PMC7751278.
Chaix A, Manoogian ENC, Melkani GC, Panda S. Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases. Annu Rev Nutr. 2019;39:291-315. Epub 2019/06/11. doi: 10.1146/annurev-nutr-082018-124320. PubMed PMID: 31180809; PMCID: PMC6703924.
Chaix A, Panda S. Timing tweaks exercise. Nat Rev Endocrinol. 2019;15(8):440-1. Epub 2019/06/21. doi: 10.1038/s41574-019-0229-z. PubMed PMID: 31217576; PMCID: PMC6644656.
Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AFM, Ross DS, Saghatelian A, Panda S, Dow LE, Metallo CM, Shaw RJ. Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. Cell Rep. 2019;26(1):192-208 e6. Epub 2019/01/04. doi: 10.1016/j.celrep.2018.12.036. PubMed PMID: 30605676; PMCID: PMC6344045.
Manoogian ENC, Chaix A, Panda S. When to Eat: The Importance of Eating Patterns in Health and Disease. J Biol Rhythms. 2019;34(6):579-81. Epub 2019/12/10. doi: 10.1177/0748730419892105. PubMed PMID: 31813351; PMCID: PMC7213043.
2016
Chaix A, Panda S. Ketone Bodies Signal Opportunistic Food-Seeking Activity. Trends Endocrinol Metab. 2016;27(6):350-2. Epub 2016/04/04. doi: 10.1016/j.tem.2016.03.014. PubMed PMID: 27038664; PMCID: PMC4903165.
Chaix A, Zarrinpar A, Panda S. The circadian coordination of cell biology. J Cell Biol. 2016;215(1):15-25. Epub 2016/10/16. doi: 10.1083/jcb.201603076. PubMed PMID: 27738003; PMCID: PMC5057284.
2015
Chaix A, Zarrinpar A. The effects of time-restricted feeding on lipid metabolism and adiposity. Adipocyte. 2015;4(4):319-24. Epub 2015/10/10. doi: 10.1080/21623945.2015.1025184. PubMed PMID: 26451290; PMCID: PMC4573188.
Mingueneau M, Chaix A, Scotti N, Chaix J, Reynders A, Hammond C, Thimonier J. Hands-on experiments on glycemia regulation and type 1 diabetes. Adv Physiol Educ. 2015;39(3):232-9. Epub 2015/09/04. doi: 10.1152/advan.00047.2015. PubMed PMID: 26330044.
Mingueneau M, Chaix A, Scotti N, Chaix J, Reynders A, Hammond C, Thimonier J. A multidisciplinary guided practical on type I diabetes engaging students in inquiry-based learning. Adv Physiol Educ. 2015;39(4):383-91. Epub 2015/12/03. doi: 10.1152/advan.00045.2015. PubMed PMID: 26628664.
Zarrinpar A, Chaix A, Panda S. Daily Eating Patterns and Their Impact on Health and Disease. Trends Endocrinol Metab. 2016;27(2):69-83. Epub 2015/12/27. doi: 10.1016/j.tem.2015.11.007. PubMed PMID: 26706567; PMCID: PMC5081399.
2014
Chaix A, Zarrinpar A, Miu P, Panda S. Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab. 2014;20(6):991-1005. Epub 2014/12/04. doi: 10.1016/j.cmet.2014.11.001. PubMed PMID: 25470547; PMCID: PMC4255155.
Zarrinpar A, Chaix A, Yooseph S, Panda S. Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. Cell Metab. 2014;20(6):1006-17. Epub 2014/12/04. doi: 10.1016/j.cmet.2014.11.008. PubMed PMID: 25470548; PMCID: PMC4255146.
2013
Chaix A, Arcangeli ML, Lopez S, Voisset E, Yang Y, Vita M, Letard S, Audebert S, Finetti P, Birnbaum D, Bertucci F, Aurrand-Lions M, Dubreuil P, De Sepulveda P. KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570. Oncogene. 2014;33(7):872-81. Epub 2013/02/19. doi: 10.1038/onc.2013.12. PubMed PMID: 23416972.
Plikus MV, Vollmers C, de la Cruz D, Chaix A, Ramos R, Panda S, Chuong CM. Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling. Proc Natl Acad Sci U S A. 2013;110(23):E2106-15. Epub 2013/05/22. doi: 10.1073/pnas.1215935110. PubMed PMID: 23690597; PMCID: PMC3677499.
2010
Chaix A, Lopez S, Voisset E, Gros L, Dubreuil P, De Sepulveda P. Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells. J Biol Chem. 2011;286(8):5956-66. Epub 2010/12/08. doi: 10.1074/jbc.M110.182642. PubMed PMID: 21135090; PMCID: PMC3057865.
Voisset E, Lopez S, Chaix A, Georges C, Hanssens K, Prebet T, Dubreuil P, De Sepulveda P. FES kinases are required for oncogenic FLT3 signaling. Leukemia. 2010;24(4):721-8. Epub 2010/01/30. doi: 10.1038/leu.2009.301. PubMed PMID: 20111072.
Voisset E, Lopez S, Chaix A, Vita M, George C, Dubreuil P, De Sepulveda P. FES kinase participates in KIT-ligand induced chemotaxis. Biochem Biophys Res Commun. 2010;393(1):174-8. Epub 2010/02/02. doi: 10.1016/j.bbrc.2010.01.116. PubMed PMID: 20117079.
Yang Y, Letard S, Borge L, Chaix A, Hanssens K, Lopez S, Vita M, Finetti P, Birnbaum D, Bertucci F, Gomez S, de Sepulveda P, Dubreuil P. Pediatric mastocytosis-associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KIT-phosphotransferase domain mutations. Blood. 2010;116(7):1114-23. Epub 2010/05/21. doi: 10.1182/blood-2009-06-226027. PubMed PMID: 20484085.